Hyperintense Vessels on Acute Stroke Fluid-Attenuated Inversion Recovery Imaging: Associations With Clinical and Other MRI Findings
Identifieur interne : 005B75 ( Main/Exploration ); précédent : 005B74; suivant : 005B76Hyperintense Vessels on Acute Stroke Fluid-Attenuated Inversion Recovery Imaging: Associations With Clinical and Other MRI Findings
Auteurs : Bastian Cheng [Allemagne] ; Martin Ebinger [Allemagne] ; Anna Kufner [Allemagne] ; Martin Köhrmann [Allemagne] ; Ona Wu [États-Unis] ; Dong-Wha Kang [Corée du Sud] ; David Liebeskind [États-Unis] ; Thomas Tourdias [France] ; Oliver C. Singer [Allemagne] ; Soren Christensen [Australie] ; Steve Warach [États-Unis] ; Marie Luby [États-Unis] ; Jochen B. Fiebach [Allemagne] ; Jens Fiehler [Allemagne] ; Christian Gerloff [Allemagne] ; Götz Thomalla [Allemagne]Source :
- Stroke : (1970) [ 0039-2499 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background and Purpose-Hyperintense vessels (HVs) have been observed in fluid-attenuated inversion recovery imaging of patients with acute ischemic stroke and been linked to slow flow in collateral arterial circulation. Given the potential importance of HV, we used a large, multicenter data set of patients with stroke to clarify which clinical and imaging factors play a role in HV. Methods-We analyzed data of 516 patients from the previously published PRE-FLAIR study (PREdictive value of FLAIR and DWI for the identification of acute ischemic stroke patients ≤3 and ≤4.5 hours of symptom onset-a multicenter study) study. Patients were studied by MRI within 12 hours of symptom onset. HV were defined as hyperintensities in fluid-attenuated inversion recovery corresponding to the typical course of a blood vessel that was not considered the proximal, occluded main artery ipsilateral to the diffusion restriction. Presence of HV was rated by 2 observers and related to clinical and imaging findings. Results-Presence of HV was identified in 240 of all 516 patients (47%). Patients with HV showed larger initial ischemic lesion volumes (median, 12.3 versus 4.9 mL; P<0.001) and a more severe clinical impairment (median National Institutes of Health Stroke Scale 10.5 versus 6; P<0.001). In 198 patients with MR angiography, HVs were found in 80% of patients with vessel occlusion and in 17% without vessel occlusion. In a multivariable logistic regression model, vessel occlusion was associated with HV (OR, 21.7%; 95% CI, 9.6-9.9; P<0.001). HV detected vessel occlusion with a specificity of 0.86 (95% CI, 0.80-0.90) and sensitivity of 0.76 (95% CI, 0.69-0.83). Conclusions-HVs are a common finding associated with proximal arterial occlusions and more severe strokes. HVs predict arterial occlusion with high diagnostic accuracy.
Url:
Affiliations:
- Allemagne, Australie, Corée du Sud, France, États-Unis
- Aquitaine, Bavière, Berlin, District de Moyenne-Franconie, Hambourg, Nouvelle-Aquitaine, Région capitale de Séoul, Victoria (État)
- Berlin, Bordeaux, Erlangen, Hambourg, Melbourne, Séoul
- Université de Melbourne
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Hyperintense Vessels on Acute Stroke Fluid-Attenuated Inversion Recovery Imaging: Associations With Clinical and Other MRI Findings</title>
<author><name sortKey="Cheng, Bastian" sort="Cheng, Bastian" uniqKey="Cheng B" first="Bastian" last="Cheng">Bastian Cheng</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitatsklinikum Hamburg-Eppendorf</s1>
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<wicri:noRegion>National Institute of Neurological Disorders and Stroke</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fiebach, Jochen B" sort="Fiebach, Jochen B" uniqKey="Fiebach J" first="Jochen B." last="Fiebach">Jochen B. Fiebach</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centrum für Schlaganfallforschung Berlin, Charite-Universitatsmedizin Berlin</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Unversitatsklinikum Hamburg-Eppendorf</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitatsklinikum Hamburg-Eppendorf</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitatsklinikum Hamburg-Eppendorf</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Stroke : (1970)</title>
<title level="j" type="abbreviated">Stroke : (1970)</title>
<idno type="ISSN">0039-2499</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Stroke : (1970)</title>
<title level="j" type="abbreviated">Stroke : (1970)</title>
<idno type="ISSN">0039-2499</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrovascular disease</term>
<term>Diffusion</term>
<term>Inversion recovery</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Stroke</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Accident cérébrovasculaire</term>
<term>Pathologie du système nerveux</term>
<term>Pathologie cérébrovasculaire</term>
<term>Retour inversion</term>
<term>Imagerie RMN</term>
<term>Diffusion</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background and Purpose-Hyperintense vessels (HVs) have been observed in fluid-attenuated inversion recovery imaging of patients with acute ischemic stroke and been linked to slow flow in collateral arterial circulation. Given the potential importance of HV, we used a large, multicenter data set of patients with stroke to clarify which clinical and imaging factors play a role in HV. Methods-We analyzed data of 516 patients from the previously published PRE-FLAIR study (PREdictive value of FLAIR and DWI for the identification of acute ischemic stroke patients ≤3 and ≤4.5 hours of symptom onset-a multicenter study) study. Patients were studied by MRI within 12 hours of symptom onset. HV were defined as hyperintensities in fluid-attenuated inversion recovery corresponding to the typical course of a blood vessel that was not considered the proximal, occluded main artery ipsilateral to the diffusion restriction. Presence of HV was rated by 2 observers and related to clinical and imaging findings. Results-Presence of HV was identified in 240 of all 516 patients (47%). Patients with HV showed larger initial ischemic lesion volumes (median, 12.3 versus 4.9 mL; P<0.001) and a more severe clinical impairment (median National Institutes of Health Stroke Scale 10.5 versus 6; P<0.001). In 198 patients with MR angiography, HVs were found in 80% of patients with vessel occlusion and in 17% without vessel occlusion. In a multivariable logistic regression model, vessel occlusion was associated with HV (OR, 21.7%; 95% CI, 9.6-9.9; P<0.001). HV detected vessel occlusion with a specificity of 0.86 (95% CI, 0.80-0.90) and sensitivity of 0.76 (95% CI, 0.69-0.83). Conclusions-HVs are a common finding associated with proximal arterial occlusions and more severe strokes. HVs predict arterial occlusion with high diagnostic accuracy.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Corée du Sud</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Aquitaine</li>
<li>Bavière</li>
<li>Berlin</li>
<li>District de Moyenne-Franconie</li>
<li>Hambourg</li>
<li>Nouvelle-Aquitaine</li>
<li>Région capitale de Séoul</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Berlin</li>
<li>Bordeaux</li>
<li>Erlangen</li>
<li>Hambourg</li>
<li>Melbourne</li>
<li>Séoul</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Cheng, Bastian" sort="Cheng, Bastian" uniqKey="Cheng B" first="Bastian" last="Cheng">Bastian Cheng</name>
</region>
<name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name>
<name sortKey="Fiebach, Jochen B" sort="Fiebach, Jochen B" uniqKey="Fiebach J" first="Jochen B." last="Fiebach">Jochen B. Fiebach</name>
<name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name>
<name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name>
<name sortKey="Kohrmann, Martin" sort="Kohrmann, Martin" uniqKey="Kohrmann M" first="Martin" last="Köhrmann">Martin Köhrmann</name>
<name sortKey="Kufner, Anna" sort="Kufner, Anna" uniqKey="Kufner A" first="Anna" last="Kufner">Anna Kufner</name>
<name sortKey="Singer, Oliver C" sort="Singer, Oliver C" uniqKey="Singer O" first="Oliver C." last="Singer">Oliver C. Singer</name>
<name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Wu, Ona" sort="Wu, Ona" uniqKey="Wu O" first="Ona" last="Wu">Ona Wu</name>
</noRegion>
<name sortKey="Liebeskind, David" sort="Liebeskind, David" uniqKey="Liebeskind D" first="David" last="Liebeskind">David Liebeskind</name>
<name sortKey="Luby, Marie" sort="Luby, Marie" uniqKey="Luby M" first="Marie" last="Luby">Marie Luby</name>
<name sortKey="Warach, Steve" sort="Warach, Steve" uniqKey="Warach S" first="Steve" last="Warach">Steve Warach</name>
</country>
<country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kang, Dong Wha" sort="Kang, Dong Wha" uniqKey="Kang D" first="Dong-Wha" last="Kang">Dong-Wha Kang</name>
</region>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tourdias, Thomas" sort="Tourdias, Thomas" uniqKey="Tourdias T" first="Thomas" last="Tourdias">Thomas Tourdias</name>
</region>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Christensen, Soren" sort="Christensen, Soren" uniqKey="Christensen S" first="Soren" last="Christensen">Soren Christensen</name>
</region>
</country>
</tree>
</affiliations>
</record>
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